Luther

Genetic Testing

Dobermans like every other breed are prone to certain genetic disorders. It's important to educate yourself about these disorders so you can understand them. Kiziah's Dobermans is very careful in the lines we've bred through the years. We test hips, eyes, and blood on all of our breeding dogs and will provide copies of all testing with each puppy purchased.

Below is a detailed list of the types of genetic disorders tht can be found in the genetic make up of Dobermans. At Kiziah Dobermans we take specail care to test of our breeding dogs for the followiing genetic diorders.

CARDIOMYOPATHY -
is suspected to be an inherited disease in Dobermans. Research is in progress in several institutions. An echocardiogram of the heart will confirm the disease but WILL not guarantee that the disease will not develop in the future.

HIP DYSPLASIA -
is inherited. It may vary from slightly poor conformation to malformation of the hip joint allowing complete luxation of the femoral head. Both parents' hips should be OFA certified - excellent, good or fair rating.

HYPOTHYROIDISM -
is inherited and means that the thyroid gland is not producing enough hormone to adequately maintain the dog's metabolism. It is easily treated with thyroid replacement pills on a daily basis. Thyroid testing (T3, T4, TSH and autoantibodies) should be performed on an annual schedule. Finding autoantibodies to thyroglobulin (T4 autoantibodies) is an indication that the dog has "Hashimoto's Disease". Low thyroid dogs, manifested by a high TSH and a low T4, should be treated and monitored on a regular basis.

vWd (VON WILLEBRAND'S DISEASE) -
is an autosomally (not sex linked) inherited bleeding disorder with a prolonged bleeding time and a mild to severe factor IX deficiency. Von Willebrand's factor antigens of 70% 180% are considered to be within the normal range for Dobermans. When dogs are tested through the Elisa assay blood test for vWD, they are tested for carrier status only NOT the disease. It is believed that carrier status tests (Elisa assay) are inaccurate if a dog is ill, received any medication or vaccination within 14 days of testing, pregnancy, bitches in heat or lactation. Stress conditions (infections, parasites, hormonal changes, trauma, surgery, emotional upset, etc.) may have an effect on the outcome of the vWD blood test and might be a contributing factor for bleeding tendencies. vWD carrier status is quite common in Dobermans. A DNA test for vWD is available - genetically: clear, carrier (inherited one disease gene), affected (inherited two disease genes) - results are not effected by stress conditions, etc.

WOBBLER'S SYNDROME -
is suspected to be an inherited condition in Dobermans. Dogs suffer from spinal cord compression caused by cervical vertebral instability or from a malformed spinal canal. This results in an unsteady (wobbly) gait and weakness. Treatment is either medical to control the symptoms, usually with corticosteroids and cage rest, or surgical to correct the spinal cord compression. Either way, there is no real cure for the disease and relapses are likely to occur.

PRA (PROGRESSIVE RETINAL ATROPHY) -
is an inherited condition in Dobermans. Clinically, visual acuity is diminished, first at dusk, later in daylight. The disease progresses over months or years, to complete blindness. A screening test is available and can be performed by a veterinary ophthalmologist. CERF (Canine Eye Registration Foundation) will certify eyes for 12 months from the date of evaluation.

ALBINISM -
"white coated" and "white factored" Dobermans should NOT be bred. These dogs are *TYROSINASE POSITIVE ALBINOS*. In 1996, the AKC established a tracking system (the letter "Z" will be part of the registration number) allowing breeders to identify the normal colored Dobermans which may carry the albinistic gene. A list with all dogs tracing back to Shebah's (the first Albino Doberman registered) parents is available from the DPCA. All breeders should require an AKC certified pedigree with colors to check that "white coated" and "white factored" dogs are not present in the pedigree of the dog or bitch to be bred.